Mencap on Remloy factory closures
7 March 2012 Last updated at 18:18 GMT
Remploy - which provides work for people with disabilities - is planning to close 36 of its 54 factories, putting more than 1,700 jobs at risk.
Minister for Disabled People Maria Miller said the sites could be closed by the end of the year as they were not financially viable.
Remploy factories were established 66 years ago as part of the creation of the welfare state.
Mark Goldring, Chief Executive, Mencap thinks it is a deeply sad moment when anyone with a disability loses their jobs. But he welcomed any plans to promote more employment in the wider economy.