Three-person IVF moves closer in UK

 
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The UK has moved closer to becoming the first country to allow the creation of babies from three people.

The Human Fertilisation and Embryology Authority (HFEA) has advised the government that there is no evidence the advanced forms of IVF were unsafe.

The fertility regulator's public consultation also showed "general support" for the idea as the benefits outweighed the risks.

A final decision on whether to press ahead rests with ministers.

If the techniques were approved it could help a handful of families each year. Around one in 6,500 children develop serious "mitochondrial disorders" which are debilitating and fatal.

The woman who lost all her children

Sharon Bernardi and her son Edward, who died last year aged 21

Every time Sharon Bernardi became pregnant, she hoped for a healthy child.

But all seven of her children died from a rare genetic disease that affects the central nervous system - three of them just hours after birth.

When her fourth child, Edward, was born, doctors discovered the disease was caused by a defect in Sharon's mitochondria.

Edward was given drugs and blood transfusions to prevent the lactic acidosis (a kind of blood poisoning) that had killed his siblings.

Five weeks later Sharon and her husband, Neil, were allowed to take Edward to their home in Sunderland for Christmas - but his health slowly began to deteriorate.

Edward survived into adulthood, dying in 2011 at the age of 21.

Now Sharon is supporting medical research that would allow defective mitochondria to be replaced by DNA from another woman.

Research suggests that using mitochondria from a donor egg can prevent the diseases.

However, it would result in babies having DNA from two parents and a tiny amount from a third donor.

Concerns have been raised both about the safety and the ethics of creating such babies.

The results of a public consultation at the end of 2012 showed there was support for the idea.

Prof Neva Haites, who was on the expert panel supervising the consultation, said: "Broadly speaking the public was in favour of these novel techniques being translated into treatments.

"They felt that any ethical concerns were outweighed by potential benefits."

One of the main issues raised was of a "slippery slope" which could lead to other forms of genetic modification.

'Power stations'

Mitochondria are the tiny biological power stations that give energy to nearly every cell of the body.

Defects can leave the body starved of energy, resulting in muscle weakness, blindness, heart failure and death in the most extreme cases.

The cigar-shaped mitochondria are passed only from mother to child. A father does not pass on his mitochondria through his sperm.

Scientists have devised two techniques that allow them to take the genetic information from the mother and place it into the egg of a donor with healthy mitochondria. It is like taking two fried eggs and switching the yolks.

How would it work?
Method one: Embryo repair 1) Two eggs are fertilised with sperm, creating an embryo from the intended parents and another from the donors 2) The pronuclei, which contain genetic information, are removed from both embryos but only the parents' is kept 3) A healthy embryo is created by adding the parents' pronuclei to the donor embryo, which is finally implanted into the womb
Method two: Egg repair 1) Eggs from a mother with damaged mitochondria and a donor with healthy mitochondria are collected 2) The majority of the genetic material is removed from both eggs 3) The mother's genetic material is inserted into the donor egg, which can be fertilised by sperm.

The result is a baby with genetic information from three people, as mitochondria have their own genes in their own DNA.

The implications are not just for the couple and the child. If the therapy was performed it would have ramifications through the generations as scientists would be altering human genetic inheritance.

'Recommendations'

The HFEA has advised that any changes to the law should be only for the modification of mitochondria to overcome serious diseases and that there should still be a ban on changes to the main nuclear DNA, which contains the vast majority of a person's genetic code.

It also recommended continuing research and that any children born through these techniques, and possible the children's children, be monitored closely.

Any time soon?

These therapies using sperm and eggs from three people are not yet ready to be performed in the clinic. However, it is thought that scientists in the UK and the US are getting close to the point where it will be possible.

Prof Robin Lovell-Badge, part of the expert panel analysing the science, said there was "still no evidence to suggest the techniques are unsafe," but he said further experiments were needed for reassurance.

"Safety is absolutely not a black and white issue. In reproductive medicine in particular it is not possible to be absolutely certain about the consequences of any new treatment until children are born.

"Someone at some point is going to have to take the brave decision to go ahead with it."

Some of the researchers involved believe they may be ready to make the leap in three to five years - if everything goes to plan, something which is by no means certain.

There was vigorous discussion at the HFEA Open Meeting, where the advice to ministers was agreed, around issues of identification. In sperm and egg donation the donor is identified.

The meeting agreed to advise ministers that there should be no right for the child to know the identity of the donor, however, the HFEA will tell ministers that public opinion was mixed.

Mr Hossam Abdalla, clinical director of the Lister Fertility Clinic in London, told the meeting: "If a child wants to know about that, why are we so restrictive... why are we telling them we they can't have this access?"

'Astounded'

Prof Lisa Jardine, chairwoman of the HFEA, said the UK was in one of the most advanced positions in the world.

"Other countries are astounded that we're this far on in the discussions," she said.

However, she pointed out the techniques would be used only for mitochondrial disorders: "This is not a Rubicon or a slippery slope."

One of the pioneers of the field, Prof Doug Turnbull, from Newcastle University, said: "The techniques we are working on could help hundreds of women have healthy children."

He said more research was required, but it was now "crucial" that the government approved the techniques in the UK.

The Department of Health said mitochondrial diseases could have a "devastating impact" on families and it would consider the HFEA's advice.

Making three-person IVF legal would not require a new act of Parliament, but would require a vote in both the Commons and the Lords.

Speaking after the meeting Dr David King, the director of Human Genetics Alert, said: "Historians of the future will point to this as the moment when technocrats crossed the crucial line, the decision that led inexorably to the disaster of genetically engineered babies and consumer eugenics.

"This was the moment at which they casually tossed the bioethical consensus of the last 30 years into the trash. And for what?

"Not so mothers could avoid having sick babies, because they could do that already, through egg donation. It was so that a few dozen mothers who insisted they must be genetically related to their child could be satisfied."

 

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  • rate this
    +5

    Comment number 227.

    @160.
    benbowlane

    What a sick world we live in
    --------
    In an age where adults would let children grow up with debilatating illnesses because it conflicts with their so called morality...

    The world is far sicker then you know

  • rate this
    -4

    Comment number 226.

    IVF is a risk to the child, and should be banned. BBC on 6 June 2012: "IVF higher risk of complication. There is a higher risk of complications and multiple births in pregnancies that result from IVF techniques, say experts."

  • rate this
    0

    Comment number 225.

    216.
    Jabdi
    "No yet again you need to read the article and identify the area where it illustrates that Human DNA is not being altered, but mitochondrial DNA"

    If you are a scientist I have to respect what you say is correct. My point is that our knowledge is at a level where a mistake could have big ramifications for future generations.
    .

  • rate this
    -1

    Comment number 224.

    So they are trying to create a Bramley Apple here.
    No idea what I am talking about?
    Look up how Bramley became the only apple tree that needs two other blossoms to enable it to bear fruit.
    Get my drift?

  • rate this
    -5

    Comment number 223.

    British freakshow

  • rate this
    -1

    Comment number 222.

    Continuation of what hitler wanted which now gets public funding and will one day make us drones, weed out our freedom to believe ergo zombies.
    218 like you say where does it end?

  • rate this
    0

    Comment number 221.

    There seems to be a lot of posts that blur the lines between this and Medicine/Healthcare.

    Medicine is about improving the quality of life for the living.

    This is about genetic engineering and artificially creating new life.

    They are two separate issues in my mind with different moral/humanitarian considerations.

  • rate this
    +5

    Comment number 220.

    I fully support this as I am someone who has a mitocondria disease. Why shouldn't I have the chance to try for a family in a controlled way to prevent the heart break of loosing a child, or having a child with a life affecting diability and watching them suffer and then still die.

  • rate this
    +2

    Comment number 219.

    dear sarcasm,
    its not just Christians who believe in God. I saw your comment and was going to reply the 'just beacause some humans commit murder it does not make all humans murderers'. I would say, lighten up for Gods' sake but I think my irony chip would explode!!!

  • rate this
    +1

    Comment number 218.

    Every journey starts with just one step.

    This is just another step in a journey, genetic engineering wont end here, it will continue onwards from here.

    We will see genetically engineered humans created to be slaves to the state.

  • rate this
    -2

    Comment number 217.

    Look at the last hundred years til now to get a scale of the devestation we have had on the earth and animals fish ect. If only we survive do not balk at eating horse as you will be eating human flesh, or are our great scientists going to invent new life forms for us to eat?

  • rate this
    +2

    Comment number 216.

    213. oldm8

    No yet again you need to read the article and identify the area where it illustrates that Human DNA is not being altered, but mitochondrial DNA.

    Mitochondria are ancient prokaryotes, with the same ancestors and modern day bacteria. They work symbiotically with humans, but when they do not work properly, disease ensues.

  • rate this
    +1

    Comment number 215.

    Bruxical...are you talking about natural selection? Because that's been irrelevant in the human species for ages. We're already too advanced for it to matter, so why not fix what we can?

  • rate this
    +4

    Comment number 214.

    Re: Post 83 by Green Man: "The religious argument against this seems to boil down to "God wants these babies to die""

    And suffer into the bargain. Nice.

  • rate this
    +1

    Comment number 213.

    "If the therapy was performed it would have ramifications through the generations as scientists would be altering human genetic inheritance" therein lies the risk. If a single therapy is subsequently found to be ill conceived say in 500 years it will be too late when over 1 million people will have the alteration. We have only just discovered that 'junk DNA' is not junk.

  • rate this
    0

    Comment number 212.

    Whist I have every sympathy for couples who can't have children via the normal process I do think in a world of finite resources, which includes doctors, nurses etc we should be concentrating our efforts in improving the lives of those already here. if all the money that has been spent on IVF Research etc had been spent in Cancer Recearch instead, we may may already have had a cure.

  • rate this
    0

    Comment number 211.

    As one half of an unsuccessful IVF intervention some years ago take note this process is not for the faint hearted. Conventional IVF has considerable risks to the potential mother over and above a natural conception. Consider also this new process introduces a further layer of risk along with unknown outcomes for the potential child. If offered think VERY carefully and live by your decision.

  • rate this
    0

    Comment number 210.

    "82. House76
    If we're going to have 3 parent children, does this mean we will be having 3 Person Marriages too?"
    No, unless science finds a way to redesign the sexual organs; otherwise one will always be left behind in the intimate moments and that will be just too cruel...

  • rate this
    0

    Comment number 209.

    If it helps people, why not.

  • rate this
    -3

    Comment number 208.

    Screening for blonde hair and blue eyes next?

 

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