Hopes raised of blocking return of leukaemia

Blood with myeloid leukaemia Acute leukaemia has a high relapse rate

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Scientists are working on a way to stop one of the most aggressive forms of acute leukaemia, MLL, returning after a patient has received treatment.

Recurrence of the blood cancer caused by rogue leukaemic stem cells is a major problem for doctors.

But a team at King's College London, working on mice, have raised hopes of a solution.

They describe in the journal Cell Stem Cell how they eliminated the stem cells by suppressing two key proteins.

It is hoped the work, funded by Cancer Research UK and Leukaemia Lymphoma Research, will lead to new treatments which will enable complete remission for patients with a form of acute leukaemia.

Cancer stem cells appear to be more resistant than other leukaemia cells to standard treatments, such as radiotherapy and chemotherapy.

So even after treatment appears to have been initially successful, they can remain to trigger a new round of disease, which often reappears in a more aggressive form.

More than 50% of acute leukaemia patients will relapse and survival is poor, with fewer than half living for five years.

The King's team looked at leukaemic stem cells found in a type of acute leukaemia involving mutations in a gene called MLL.

This particularly aggressive form of the disease accounts for about 70% of infant leukaemias, and 10% of adult acute leukaemias.

Only half of children diagnosed with the disease survive for two years after receiving standard treatment.

Double assault

A protein called Bmi1 was already known to play a key role in the survival and proliferation of various cancer stem cells.

Start Quote

This research is important in uncovering how leukaemia stem cells are controlled at the genetic level which, in turn, will guide new treatments to tackle this difficult problem”

End Quote Dr David Grant Leukaemia & Lymphoma Research

But the King's team showed that targeting Bmi1 alone was not enough to eradicate the rogue stem cells, as had previously been thought.

To do that, the scientists found that Bmi1 had to be targeted in harness with a second protein, Hoxa9.

This double assault abolished the ability of MLL mutation to induce leukaemia.

Researcher Professor Eric So said: "These findings take us a step forward in our understanding of how this devastating disease can return in patients after they have received the standard treatment.

"Now we know that leukaemic stem cells in certain types of leukaemia, such as MLL, can survive and proliferate independently of the Bmi1 protein, we need to consider more carefully the future of stem cell therapy to treat the disease.

"It's not as easy as people originally thought it might be."

Professor So said the next step would be to pin down exactly how the two proteins help cancer cells to grow.

Professor Peter Johnson, Cancer Research UK's chief clinician, said: "Cancer stem cells appear to be more resistant to radiotherapy and chemotherapy than the other leukaemia cells, so understanding how they originate - and how we can kill them - will be a major step in being able to help even more people survive leukaemia in future."

Dr David Grant, scientific director of Leukaemia & Lymphoma Research, said: "It is now widely agreed that leukaemia stem cells are the true target for new or existing drugs if patients are to be cured.

"This research is important in uncovering how leukaemia stem cells are controlled at the genetic level which in turn will guide new treatments to tackle this difficult problem."

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