Frank Infante (born 15 November 1951) is an American guitarist and bassist best known as a former member of the new wave band Blondie.
Prior to Blondie, he established himself playing guitar in heavy, electric blues groups such as The Elegant End and World War III. In 1975, he joined Sniper. Infante joined Blondie in 1977 as a session player. The group had been formed three years earlier by singer Deborah Harry and guitar player Chris Stein, out of the remnants of Harry's previous group, The Stilettos. Gary Valentine was the band's bassist that August but was replaced by Infante in July 1977.
Chrysalis Records took over Blondie's contract from Private Stock Records, and in February 1978, the band released their second album, Plastic Letters. Infante played on the record but was not pictured on the album cover. He continued to play bass for Blondie until Nigel Harrison joined the group later that year, at which point Harrison took over the role of bass player and Infante switched to guitar. Both Infante and Harrison stayed with the band until it broke up in 1982, but neither were included when Blondie reformed in the late 1990s. Infante and Harrison sued the other members of the band for reforming the band without them, but were unsuccessful.