Brendan O'Brien (born June 23, 1960 in Atlanta, Georgia) is a record producer, mixer, engineer, and musician.
At age 14, O'Brien played guitar for the Atlanta-based cover band Pranks. In the late 1970s, he moved on to writing, performing and recording with the band Samurai Catfish. In the 1980s, he performed studio work with many local artists, including the Indigo Girls and the Downtown Executives, and played bass with The Georgia Satellites for a short time. He played guitar on the Atlanta Rhythm Section's 1989 album Truth in a Structured Form. His studio career was propelled by the success of the first Black Crowes album, Shake Your Money Maker, on which he played guitar and bass and engineered.
Along with his wife Robin and three daughters Jackie, Allie, and Hannah, O'Brien left his home base of Atlanta in the early 1990s to pursue his career in Los Angeles. He began working at Geffen Records under Rick Rubin, producing bands like Stone Temple Pilots and Pearl Jam. O'Brien returned to Atlanta in 1991.