What is it?Gorlin syndrome - also known as nevoid basal cell carcinoma syndrome - causes a variety of problems, mostly affecting the skin and connective tissues. People with the syndrome have a predisposition to multiple basal cell carcinomas (a form of skin cancer), jaw cysts and other generally harmless abnormalities in the bone. The severity of the disease can be wide-ranging. CausesGorlin syndrome is an autosomal dominant condition. The abnormal gene is found on chromosome 9. New mutations (where neither parent carries the gene) are common. TreatmentAlthough there's no cure, the carcinomas can be treated by surgery, lasers or photodynamic therapy, which reduces scarring. If there's a family history of the syndrome, it's possible for family members to be tested to see if they carry the faulty gene. Those with Gorlin syndrome are now advised to avoid - or to take advice before undergoing - any radiation treatment, as it's thought it may exacerbate the condition.
This article was last medically reviewed by Dr Rob Hicks in April 2008
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