The men's time trial gets under way at 1200 BST in Varese, with the event rated as one of the most open in years.
There's no Fabian Cancellara, the defending champion and Olympic gold medallist, but there is still a high-quality field on display in Italy.
Britain's Stephen Cummings and David Millar are in the mixer, but they wil have to look out for the likes of three-time winner Michael Rogers and Olympic silver medallist Gustav Larsson.
Don't forget that UK users will be able to follow all the action as it happens on the live video feed on the website, or on the red button at home.
And there will also be a live text commentary to keep you up to date with all the comings and goings in Varese, so keep your thoughts and comments coming in on text (81111) or on this thread.
Who do you fancy to come out on top? Any unheralded names to look out for? And how will the Brits get on?