The firm is to hold auditions over three days in May to coincide with the launch of its new feature artists management division.
SWM&C, formerly the South West Casting agency, was taken over by businessman David Mills in December 2004. He moved the firm from Ross-on-Wye to Bristol.
Until then, it primarily acted as a consultant for film companies and as an agency for movie and television extras.
The firm, which claims actor Paul McGann as its patron, has more than 4,000 'supporting artists' on its books and has worked for companies including Touchstone Pictures and Tiger Aspect.
Now, SWM&C is aiming to recruit dozens of feature actors - performers, usually formally trained, who have lead or talking roles.
Head of casting Jesse Malone said Bristol had a burgeoning creative sector and a successful theatre school.
But actors were traditionally drawn to London because it was the centre of the entertainment industry, she said.
“There is a deep pool of acting talent but we are losing them to London, rather than championing them here,” Ms Malone said.
SWM&C believes the presence of an agency actively recruiting and representing actors for film and television will encourage students to stay on when they graduate, and also tempt working actors back to the city.
“For film companies to use the South West, they also need to know the resources are here,” Ms Malone added.
The agency’s auditions will be held from 9 to 11 May, at the Bristol Old Vic Theatre. The first audition will be for graduate actors. People without any practical experience or formal training will be auditioned on the second day. The third session will be for recalls.
A total of 30 people will be selected and will be represented and managed by SWM&C.
Applications forms can be found at SWM&C’s website from 28 February.
Alternatively, send your CV, a photograph, and any show reel to: Jesse Malone, Auditions Department, SWM&C, 2 Clare Street, Bristol, BS1 1XR.
The deadline for applications is 24 March.