When she grew up, Betsi (real name Elizabeth) was a traveller of note, working as a servant and as a companion for various people, ships captains and titled ladies among them. Her work took her around the world several times - and this in an age when most working class men, let alone working class women, never travelled more than a dozen miles from their front doors! Not officially, a nurse,
Betsi's various jobs in all parts of the world involved her in nursing duties and, in particular, convinced her of the need for cleanliness as an aid to recovery from disease and illness.
The Crimean War broke out in 1854 and, thanks to the regular despatches of journalists like William Russell, it quickly became apparent that the campaign was appallingly organised. One of the worst injustices was the total lack of care for wounded and dying soldiers.
Learning that Florence Nightingale had been commissioned to provide a cadre or squad of suitable nurses, Betsi Cadwaladr applied to join the group.
However, Nightingale had already left for Scutari and Betsi was forced to join one of the subsequent parties organised by Mrs Herbert. When she reached Scutari and met Nightingale it was clearly a clash of personalities. Apart from anything else Betsi was working class, through and through - Florence Nightingale came from a much more privileged background. Kept waiting for several weeks, Betsi fumed and demanded to be sent to the front:-
"I did not like the name Nightingale," she later commented in a book on her life. "When I first learn a name I know by my feelings whether I shall like the person who bears it."
Clearly, then, Betsi and Florence Nightingale disliked each other from the first and Nightingale eventually washed her hands of this argumentative and truculent Welsh woman who, despite all advice, made her way to the front lines where she cared for the wounded and injured soldiers.
She cooked, cleaned and nursed, working twenty hours a day and sleeping, when she found the time, on the floor with seven other nurses. Inevitably such conditions took their toll on a woman who was already over seventy years of age.
When Nightingale visited the battlefront and saw the amazing work that Betsi had done, she changed her mind about a woman who she had previously considered only to be an irritant. She begged Betsi to stay on - after a little rest - but Betsi knew her limitations and returned home
The author Jane Williams wrote a book about Betsi's life and adventures but Betsi did not live to enjoy the fruits of fame. Worn out by her exertions in the Crimea, she died on July 17 1870 and was, for many years, something of a forgotten heroine - even though she was one of a mere handful of men or women who ever dared challenge the redoubtable Florence Nightingale.
Some belated degree of recognition came in 2009 when the Betsi Cadwaladr Health Board was created to include the six local health boards along the north Wales coast. This is the largest health board in Wales, employing over 18,000 staff. Somehow, you feel, Betsi would be proud.