Does it matter about anti-matter?
This time Harvard academic Robert Langdon must foil a dastardly plot to blow up the Vatican. The twist is that the "bomb" threatening the Catholic Church is made of anti-matter stolen from CERN - the European Centre for Nuclear Research and home of the Large Hadron Collider.
The film goes to great lengths to lend an air of scientific authenticity to the action: much of the opening sequence is filmed in the underground tunnels and cavernous experimental halls that house the world's biggest particle accelerator.
Sadly, that's where Angels & Demons parts company with scientific reality.
Look a little closer and you'll see most of the hardware featured in the film is actually from the ATLAS experiment - the biggest, and admittedly most visually impressive, of the LHC's four main detectors. Looking something like an immense jet engine, but with all its components and wiring laid bare, ATLAS will search for the origins of mass, dark matter and even microscopic black holes in the high energy particle collisions at CERN.
But not anti-matter, which will actually be created and studied in the much smaller LHC-b, or beauty, experiment.
There's a problem too with the amount of anti-matter generated in the film. It would take billions of years - perhaps longer than the universe has been in existence - for the particle collisions at CERN to generate enough anti-matter to make a bomb. The film also manages to confuse anti-matter with the God particle or Higgs boson, and to imply that anti-matter somehow triggered the big bang.
But does that really matter? After all, Angels & Demons is an action packed thriller not a drama-documentary. Inevitably it takes liberties with the science, but if you're willing to suspend your disbelief it's an engaging way to spend a rainy afternoon.
That was certainly the verdict at a screening of the film laid on for scientists from CERN in Geneva last week. Angels & Demons may not be Oscar material, but it will probably run X-Men close for top spot this summer.